ABSTRACT
Rhino-orbital mucormycosis is a rare life threatening invasive fungal infection that has recently shown a very high mortality rate in India during COVID-19 pandemic. We have designed the present study to find out associations between COVID-19 induced rhino-orbital mucormycosis and concentrations of inflammatory markers, i.e. D-dimer, Ferritin, IL-6, CRP and PCT, in blood serum of Indian population. There were four groups in the study, viz. control group with healthy subjects, treatment group-1 with patients suffering from SARS-COV-2 infection, treatment group-2 with patients suffering from both SARS-COV-2 infection and rhino-orbital mucormycosis, and treatment group-3 with patients suffering from rhino-orbital mucormycosis after SARS-COV-2 infection recovery. Inflammatory markers were quantified with standard protocols, and recorded data were subjected to statistical analyses. We found that patients suffering from SARS-COV-2 infection were more susceptible to rhino-orbital mucormycosis, as they had higher concentrations of inflammatory markers in their blood than the other subjects. Diabetes mellitus, hypertension, cardiovascular diseases and renal disorders were the associated comorbidities with the patients. We also found higher concentrations of inflammatory markers in males than the females, indicating towards their higher susceptibility in developing rhino-orbital mucormycosis than females. Present study therefore suggests that the frequent occurrence of rhino-orbital mucormycosis in India during second wave of COVID-19 was possibly due to indiscriminate use of corticosteroids by COVID-19 patients. Subjects with previous history of comorbidities like diabetes mellitus, hypertension, cardiovascular disorders and renal diseases are the most susceptible population groups for developing infection. Moreover, males are at higher risk of developing mucormycosis than the females. © 2022 Innovative Publication, All rights reserved.
ABSTRACT
All over the world new and fast spreading disease have been affecting human health. This led to degradation of the living being's health immunity, support system, mental and physical stability. So the need of assistance requirement for all bed ridden patients is an increasing demand on daily basis. In our present situation the COVID-19 virus's crisis have caused a drastic change to the world. An enormous number of fields such as destruction of employment, economic losses, pandemic growth, food supplies and etc. have been affected. In this paper, an initiative step towards the replacement of man power supply to take care of COVID-19 patients have been proposed. A flex sensor glove wore by a patient would be able to communicate commands to the nurse or a care taker. The system consists of a 2.2 and 4.5 inches' flex sensors fixed over the right hand of the patient, connected with a microcontroller and wireless transmission unit. A corresponding receiver unit would be placed in the nurse station or to the care taker. The movement of patient's hand is associated to different commands. This reduces the need of the nurse to accompany a patient for 24 hours, in this crisis situation and also supports them with an electronic assistance. This flex controlled assist device have been designed and tested with an accuracy of 82.85%. © 2022 Author(s).